Aging reduces the ability of skeletal muscle to exert force and generate power, thereby predisposing affected individuals to more frequent falls and resultant injuries. The molecular basis for this loss of muscle force and power with age have been unclear. This project investigates the novel hypothesis that aging-related decreases in muscle function are due to reductions in expression of a protein called Numb. The project uses genetically modified mice, physiological testing, electron microscopy and proteomics to better understand how Numb contributes to muscle function.

The current application will provide new knowledge regarding the role of the protein called Numb in muscle function and weakness with aging. This knowledge is likely to increase our understanding of the causes of muscle weakness and could lead to treatments to prevent, mitigate weakness and frailty in the elderly.

The Cardozo Lab, led by Principal Investigator, Dr. Christopher Cardozo, M.D., is currently focused on a number of projects related to skeletal muscle health and function both in normal muscle and muscle paralyzed by a spinal cord injury, injured by trauma or impaired by disease.